Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma
Abstract Background Gestational trophoblastic disease (GTD) is a heterogeneous group of diseases developed from trophoblasts.ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and ASPP2, have been reported to be dysregulated in GTD.They modulate p53 activities and are responsible for multiple cellula